A damaged DNA sequence that is meaningful but has an incorrect meaning, with the result that its products do not do what they are supposed to do. (noun)
Examples of word missense
Genetic diseases are often caused by a specific type of genetic alteration called a missense mutation that makes cells add an incorrect amino acid into the protein chain.
DDS: These individuals carry specific alterations known as missense mutations, mostly in exons 8 or 9 of one working copy of the WT1 gene.
Three of these resulted in missense mutations in mitochondrially encoded NADH dehydrogenases 1, 2 and 4, and one caused a nonsense mutation in ATPase 6.
To confirm the HIF-1Î±-dependent regulation of 5-FU responsiveness and to further characterize the contribution of p53, we examined a second human gastric cancer cell line (MKN28), which carries a missense mutation in
The missense mutation resulted in inactivation of the autoglucosylation of glycogenin-1 that is necessary for the priming of glycogen synthesis in muscle.